Conjugate Addition of Lithiated Methyl Pyridines to Enones
نویسندگان
چکیده
منابع مشابه
Catalytic conjugate addition of allyl groups to styryl-activated enones.
Transition-metal-catalyzed conjugate addition of organometallics to activated alkenes is an important process.1 Intense research has focused on the utility of copper2 and rhodium catalysts for asymmetric additions,3 and recent efforts have led to the introduction of effective palladium4 catalysts. Each catalyst system exhibits a unique reactivity profile. The rhodium-catalyzed asymmetric conjug...
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Conjugate addition of organometallic reagents to enones to form silyl enol ether products is a versatile method to difunctionalize activated olefins, but the organometallic reagents required can be limiting. The reductive cross-electrophile coupling of unhindered primary alkyl bromides with enones and chlorosilanes to form silyl enol ether products is catalyzed by a nickel-complexed ortho-bromi...
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Synthetic methods for the selective formation of all carbon quaternary centres in non-cyclic systems are rare. Here we report highly enantioselective Cu-catalytic asymmetric conjugate addition of alkylzirconium species to twelve different acyclic trisubstituted enones. A variety of sp3-hybridized nucleophiles generated by in situ hydrozirconation of alkenes with the Schwartz reagent can be intr...
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The first enantioselective conjugate alkynylation of β-trifluoromethyl α,β-enones using terminal alkynes and a taniaphos-Cu(I) complex as catalyst is described. Ketones bearing a trifluoromethylated propargylic chiral centre in the β-position were obtained with good yields and high enantiomeric excesses (up to 99%).
متن کاملEnantioselective conjugate addition of boronic acids to enones catalyzed by O-monoacyltartaric acids.
We have found that O-monoacyltartaric acids catalyze asymmetric conjugate addition of boronic acids to enones with good enantioselectivity, and the 3,5-di(tert-butyl)benzoyl group provides the best results among the acyl groups examined.
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2010
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo100890s